Structure and function of muscarinic acetylcholine receptors.
نویسندگان
چکیده
منابع مشابه
Structure-function studies of muscarinic acetylcholine receptors.
There has been great interest in the structure-function relationships of the muscarinic acetylcholine receptors (mAChRs) because these prototypical Family A/class 1 G protein-coupled receptors (GPCRs) are attractive therapeutic targets for both peripheral and central nervous system disorders. A multitude of drugs that act at the mAChRs have been identified over the years, but many of these show...
متن کاملStructure and activation of muscarinic acetylcholine receptors.
A homology model of the M(1) muscarinic acetylcholine receptor, based on the X-ray structure of bovine rhodopsin, has been used to interpret the results of scanning and point mutagenesis studies on the receptor's transmembrane (TM) domain. Potential intramolecular interactions that are important for the stability of the protein fold have been identified. The residues contributing to the binding...
متن کاملThe role of acetylcholine muscarinic receptors in the rat basolateral amygdala on morphine-induced place preference
Some studies have shown that acetylcholine muscarinic receptors involved in the opiate reward. In the present study, the effect of intra-basolateral amygdale (BLA) acetylcholine muscarinic like receptor agonist (physostigmine) and antagonist (atropine) on the acquisition of morphine-induced place preference has been investigated in male Wistar rats. For this purpose, two 22 gauges guide cannula...
متن کاملStructure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonists, as opposed to modulators, is unknown. We created mutant M2 mAChRs in which the charge of the (172)EDGE(175) sequence had been neutral...
متن کاملThe role of acetylcholine muscarinic receptors in the rat basolateral amygdala on morphine-induced place preference
Some studies have shown that acetylcholine muscarinic receptors involved in the opiate reward. In the present study, the effect of intra-basolateral amygdale (BLA) acetylcholine muscarinic like receptor agonist (physostigmine) and antagonist (atropine) on the acquisition of morphine-induced place preference has been investigated in male Wistar rats. For this purpose, two 22 gauges guide cannula...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1988
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.28.231